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In Issue 42 of The Altascientist , we review the requirements for successful GLP-1 drug development, including: preclinical approaches early-phase clinical study design bioanalytical techniques manufacturing Two case studies are also included
Prescription of GLP-1RAs has markedly increased in the past decade [3]
Calkins BM, Mendeloff AI
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FGF21 has originally been described as a fasting hormone that is upregulated in the liver via PPAR and partly regulates ketogenesis during starvation or KDs
Popular options include Wegovy and Ozempic, both longer-acting versions of older GLP-1 medications like Victoza, Saxenda, and Trulicity
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