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Back Blume, N, Skouv, J, Larson, L-I, et al (Nov 1995) 'Potent inhibitory effects of transplantable rat glucagonomas and insulinomas on the respective endogenous islet cells are associated with pancreatic apoptosis', Journal of Clinical Investigations , 96, 2227-35
Studies on leveraging that for weight loss have been mixed
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Eli Lilly published the results of its ATTAIN-1b trial for obesity in September 2025 7 , which compared orforglipron to placebo in more than 3,100 adults without diabetes, with a BMI of 30+ or 27-30 with an obesity-related complication including hypertension, dyslipidaemia, cardiovascular disease or obstructive sleep apnoea and a history of at least one patient-reported unsuccessful dietary effort to lose body weight, who have tried unsuccessfully to lose weight with diet alone
Unlike other stomach issues that clear up quickly, constipation tends to stick around - lasting about 47 days according to clinical data [2]
What I will say: when it comes to any anti-androgen do your research, understand the risks, and exercise caution
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