The similarity in fatigue reports between active and placebo groups suggests that not all cases were causally related to AOD-9604
[10] TMG can help replenish methyl groups and facilitate the clearance of nicotinamide, theoretically reducing the buildup of by-products that could cause fatigue or headaches in some individuals
This increases the activity of sirtuins (SIRT1) and PARPs, which are essential for DNA repair and longevity
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This rigorous methodology minimizes bias and allows for accurate attribution of adverse effects to the intervention rather than background health conditions or placebo effects
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