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Ting KKY, Yu P, Iyayi M, Dow R, Hyduk SJ, Floro E, et al

FoxO3 and oxidative stress: a multifaceted role in cellular adaptation

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Cellular immunity plays a central role, with Th1 and Th17 T-helper cells, autoreactive T cells, and B lymphocytes infiltrating the gland, recruiting neutrophils, macrophages, plasma cells, and CD8 + cytotoxic T cells, leading to follicular epithelial destruction