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Gut microbial metabolites of tryptophan augment enteroendocrine cell differentiation in human colonic organoids
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Their use is limited to managing type 2 diabetes and weight-related conditions
It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)
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