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WHO/MHP/HPS/EML/2023.02

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Insulin binding stimulates phosphorylation of insulin receptor substrate-1 (IRS-1) Step 3

IVW, inverse variance weighted

evidence is largely preclinical Potent growth-factor signalling can affect blood glucose (hypoglycaemia risk) and involves proliferative pathways that need clinical oversight Screening, suitability and any monitoring are determined by the treating physician Clinical note: This card is educational and is not medical advice, a protocol or a promise of results

Some patients reach a higher dose for stronger results, while others may stay at a moderate level if they are losing weight consistently and feeling well