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Although ligand-receptor pathways are often thought of as linear paths from engagement to transcription/translation, many studies show that enhanced oxidative potential can augment or suppress signaling pathways, including those related to MUC5AC, while more recently, oxidatively driven epigenetic effects on gene transcription have also been reported (2932)

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Hasta la fecha, los ensayos clnicos en humanos siguen siendo limitados, aunque varios estn en curso o en fase de planificacin

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