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Retatrutide is being studied as a triple agonist because it also activates the glucagon receptor

As a result, the brain releases more of the hunger hormone ghrelin and dials down leptin, one of the hormones that signals fullness and energy sufficiency

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This question arises frequently as more patients begin glucagon-like peptide-1 (GLP-1) receptor agonists like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) for type 2 diabetes and weight management

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