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Side Effects and Safety Considerations While generally considered safe when administered under medical supervision, glutathione injections for purposes like skin lightening are not FDA-approved due to insufficient clinical evidence supporting their efficacy and long-term safety specifically for cosmetic use

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A prospective randomized controlled trial of Q-switched Nd:YAG laser with topical 3% tranexamic acid (TA) versus microneedling with topical 3% tranexamic acid (TA) in treatment of melasma

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The abdomen is typically the best starting site at higher body weights