are glp 1 Can one drug do it all? Reviewing the expanding clinical universe of GLP-1 agonists Science Behind GLP 1 GIP

In a 68-week clinical trial, participants receiving semaglutide experienced an average body-weight reduction of 14.9% from baseline

Glucagon-like peptide-1 receptor is present in pancreatic acinar cells and regulates amylase secretion through CAMP

What to Expect

Circulation 116(13):14821487 Ahmed A, Allman RM, Fonarow GC, Love TE, Zannad F, DellItalia LJ et al (2008) Incident heart failure hospitalization and subsequent mortality in chronic heart failure: a propensity-matched study

This is thought to be due to the GIP-induced increase in blood flow to subcutaneous adipose tissue and enhanced triglyceride clearance (22)

Lysosomal lipid peroxidation mediates immunogenic cell death