Nat Rev Endocrinol 8 , 728742 (2012)
For example, curcumin has been evaluated in Phase II clinical studies in pancreatic cancer and colorectal cancer patients, where oral doses up to 8 g/day demonstrated acceptable safety but limited systemic exposure, highlighting pharmacokinetic challenges
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This helps doctors choose the right medication when they worry about GLP-1 gastroparesis and whether it can be reversed