The symptoms of B12 deficiency The symptoms of B12 deficiency follow from the metabolic functions of vitamin B12
Insufficient intrinsic factor production, common in older adults due to age-related absorption decline, can also lead to deficiency
Capacity-Limited Elimination For drugs that exhibit capacity-limited elimination (eg, phenytoin, ethanol), clearance will vary depending on the concentration of drug that is achieved ( Table 31 )
In UK practice, monitoring is primarily based on clinical response rather than routine blood tests, as post-treatment serum B12 measurements can be misleadingly high and may not reflect tissue levels
10.1523/jneurosci.22-15-06537.2002 J
3: Matek D, Matek I, Japjec M, Matek M, Prenc J, Staresinic B, Staresinic E, Prtoric A, Sikiric S, Beketic Oreskovic L, Oreskovic I, Strbe S, Kordic M, Tvrdeic A, Seiwerth S, Sikiric P, Boban Blagaic A, Skrtic A, Bojanic I, Dobric I, Staresinic M