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In rats, the reported average was about 3.8 hours after IV dosing and 6.9 hours after oral dosing
Additionally, the microbiomes in these treatment groups were compared to both age-matched lean and obese controls
The relative abundance of Erysipelatoclostridium was increased in vehicle-treated mice that underwent the WD to LD switch (WD/LD-V) relative to the two control groups (LD/LD-V and WD/WD-V) but was not increased in 5A-1MQ-treated mice that underwent the same diet switch (WD/LD-T)
Selective NNMT inhibitor (5-amino-1MQ) reduces adiposity in DIO mice
The Kraus 2014 Nature paper established that NNMT is highly expressed in adipose tissue (especially in obesity) and that NNMT knockdown in adipose protects against diet-induced obesity in mice
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