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Insurers may require documentation of inadequate glycemic control on other medications, such as metformin, and may require step therapy demonstrating trials of less expensive alternatives before approving tirzepatide
10.1038/nature15726 46 PranziniE.PardellaE.MuccilloL.LeoA.NesiI.SantiA.et al (2022)
10.1016/j.mtbio.2023.100774 Mater Today Bio
Initially used to treat rheumatoid arthritis and multiple sclerosis, DHODH inhibitors were later found helpful in treating cancer, viral infections, and blood disorders [55,56,57,58]