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Therefore, the ratio between reduced and oxidized forms of GSH is an important indicator of the redox environment and, at the same time, contributes to the accomplishment of the molecular mechanisms underlying cell proliferation, differentiation or death in the form of apoptosis (Dickinson and Forman, 2002)
These findings highlight the critical role of stromal-tumor interactions and suggest that targeting miR-432-5p or restoring CHAC1 function could represent promising strategies to overcome chemotherapy resistance in prostate cancer (Zhao et al., 2024)
Knockdown of HSF1 and HSP-1 sensitizes cells to Erastin-induced ferroptosis, whereas protein kinase C-mediated phosphorylation of HSP-1 exerts a protective effect by reducing iron-dependent ROS accumulation, thereby inhibiting ferroptosis (35)
Despite the low sequence identities, all cytosolic GSTs share a common fold, which is also largely conserved in mitochondrial GSTs (Fig
10.1007/s00535-017-1415-1 194 SunD.ZuoC.HuangW.WangJ.ZhangZ
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