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The most common side effects are gastrointestinal , including nausea, vomiting, diarrhoea, and constipation, which typically diminish over time but can affect quality of life and potentially mood during the initial treatment period

The reduction in glutamine shunted metabolism away from the TCA cycle and decreased glutathione levels

The Pharmaceutical Journal endeavours to cover further developments about this drug class and latest associated studies in our wider content offering

The SURPASS-4 trial is the first randomized controlled trial assessing cardiovascular outcomes with Tirzepatide [45]

Can J Cardiol 2021;37:1365-77.ArticlePubMed 23

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