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Needle phobic

The skin, which previously stretched to accommodate excess adipose tissue, may not contract proportionally as fat mass decreases

Changes in circulation or shifts in body composition during significant weight reduction could potentially contribute to cramping, although this remains an area requiring further research

One person reports terrible nausea at 50 units while another feels nothing

* Correspondence: Jun Yu [email protected] Qian Liu [email protected] These authors have contributed equally to this work Specialty Section: This article was submitted to Surgical Oncology, a section of the journal Frontiers in Surgery Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers