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In the non-canonical pathway, LOS on OMVs or intracellular bacteria is first recognized by guanylate-binding proteins (GBPs) that recruit caspase-4 (murine caspase-11) (Vanaja et al., 2016

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Copper (Cu) is essential for the activation of superoxide dismutase (SOD, antioxidant defense), lysyl oxidase (collagen cross-linking), and wound-healing enzymes