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Preliminary mechanistic investigations suggest that GLP-1 medicines exert direct anti-inflammatory effects, reducing biomarkers such as C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-)

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Discussion Our findings in context In the SURPASS clinical trial program, tirzepatide at all doses studied (5 mg, 10 mg, and 15 mg) demonstrated clinically relevant reductions in the prevalence of patients meeting the criteria for metabolic syndrome following 40 or 52 weeks of treatment

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