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While co-treatment with 300 nM Ex-4 during differentiation suppressed osteogenic marker expression of RUNX2 , bone morphogenetic protein 2 ( BMP2 ), ALP and matrix deposition, early exposure prior to differentiation start or at the time of cell isolation, enhanced osteogenic marker expression [15]

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Most research protocols last 12-24 weeks to allow enough time for full body makeup changes and anti-aging effects to manifest