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GLP-1 receptor agonists the treatment of type 2 diabetes: state-of-the-art

The concept of the circadian rhythmicity in the human secretion of renin and aldosterone, under the influence of posture, sodium intake and age, is well known from decades ( Hyperglycemia and RAAS in the Kidney High glucose levels in the proximal tubule can cause increased reabsorption of glucose, sodium and water, favored by the upregulation of SGLT2 activity and expression of Na-K-2Cl cotransporter, acquaporin-2, and urea transporters, as reported in diabetic patients ( Accumulated evidence has shown that the RAAS is no longer considered to act just as an endocrine system, but also as a paracrine, autocrine and intracrine system

Eur J Obstet Gynecol Reprod Biol

Adv Pharmacol 1997;38:65-7 6

R., Thornton, J

Essentially the only way that ALC could lead to weight loss is if there is not enough around to fully metabolize all the fat and fatty acids that the body needs