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A vitamin B12 deficiency can lead to fatigue and other health-related issues

It is not approved for human or animal use and must not be administered outside controlled in-vitro research environments

While singly-housed animals may experience stress that impacts metabolism, body weight, and adiposity 65,66,67,68,69 , the singly-housed animals in this study were treated identically (to the best of the experimenters ability) to minimize and equalize stress across all animals and reduce confounding variables

Contraindications Given the limited safety data, conservative contraindications would include pregnancy or plans to become pregnant, breastfeeding, age under 18, severe liver or kidney disease, and any condition requiring medications with unknown interaction potential

Mechanism-based research considerations include: Altered methylation: NNMT inhibition affects SAM, a participant in many methylation reactions

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