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Its worth noting that IGF1R and the insulin receptor (IR) share significant structural homology and can form hybrid receptors
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When performing an intention-to-treat analysis, the HR for MOF was found to be 0.89 [0.781.02] with GLP-1 RAs compared to DPP-4is, although this became significant in the fully adjusted model (HR 0.85 [0.74 0.98])
These receptors are also present in non-islet cells and contribute to various metabolic effects in the brain, liver, adipose tissue, and gastrointestinal tract
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