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Across the SURPASS phase 3 programme versus placebo and active comparators, including semaglutide, tirzepatide has shown superior dose-dependent reductions in HbA1c levels up to 2.5% and body weight up to 13%, compared with all comparators [88-91]

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Lactobacilli can directly influence the production of interleukins (IL-1 , IL-6, IL-8, IL-2, IL-10, and IL-17) and play a role in balancing inflammation and anti-inflammation

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A/Prof Piya has received honoraria from Eli Lilly, Novo Nordisk, Boehringer Ingelheim and Johnson & Johnson

Global Health & Population Project on Access to Care for Cardiometabolic Diseases (HPACC)