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t 0), after which serial plasma aliquots were obtained at the times shown (Baseline, filled circles)

In recent GLP-1RA trials focusing on patients with obesity, favourable effect on worsening heart failure in HFpEF patients was indicated to be modulated by baseline BMI [32], although the underlying mechanisms that explain the cardiovascular and renal benefits may not necessarily be due to weight loss alone

Circadian misalignment augments markers of insulin resistance and inflammation, independently of sleep loss