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Several research studies with rodents fed a high-fat diet, different animal models of obesity and diabetes, and patients diagnosed with T2DM have all shown changes in gut microbiota caused by metformin, as shown in Table 1

Thus, new therapeutic strategies should include targeting the IGF axis in malignant cells and tumor microenvironmental drivers in prostate cancer

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In line with the link with FAO, the regulation of OCTN2 occurs via some transcription factors which also govern other proteins connected with lipid metabolism