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GERD affects 20% of adults in developed countries, and current therapies leave significant gaps
For a confirmed deficiency, their guidelines point to a specific type of B12 called hydroxocobalamin, given as an intramuscular injection
Not dosing every 7 days prevents you from hitting steady state and creates an environment of erratic side effects (both positive and negative), in addition to increasing the likelihood of negative side effects (think: nausea, GI issues, etc) as the medication works its way into and out of your system
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Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response
From the perspective of someone who has watched drug candidates rise and fall through development, the gap between how these peptides are marketed online and how rigorously they would need to be studied to earn widespread medical endorsement is enormous
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