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Although the optimal dose of LC supplementation for myocardial infarction is 3 g/day in terms of all-cause mortality [90], even lower LC intake elevates fasting plasma TMAO [16,17,18, 58, 59], which is ten-fold higher than control after 3 months of supplementation [16, 17]
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Perhaps most importantly, these effects were observed in both young and aged subjects, suggesting broad applicability across age groups