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Mechanisms underlying drug-induced ototoxicity The possible mechanisms by which ototoxic agents can influence auditory function are nerve demyelination, apoptosis via caspase cascade, glutamate toxicity, ROS overload, DNA/RNA damage, inhibition of mitochondrial protein synthesis, inner ear hypo-perfusion and ion disturbance on the background of gene mutations, and increased permeability of triggered drugs (Fig

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3.1 Bioavailability and food matrix effects HTY exhibits high intestinal absorption, with reported uptake rates approaching 8598% depending on formulation and food matrix [36, 37]

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