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If retatrutide follows the Mounjaro pattern, eligibility is likely to start with adults living with severe obesity (BMI 40+) and several weight-related conditions, then broaden in later cohorts
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In this pooled analysis of patients with heart failure and preserved ejection fraction across the SELECT, FLOW, STEP-HFpEF and STEP-HFpEF diabetes trials, semaglutide significantly reduced the risk of cardiovascular death or worsening heart failure as compared with placebo, as well as worsening heart failure events alone, but the effects on cardiovascular death were not significant, Mikhail Kosiborod, MD, FACC, FAHA, cardiologist at Saint Lukes Mid America Heart Institute and professor of medicine at the University of Missouri-Kansas City School of Medicine, said during a presentation
Others cover them with step therapy requirements (requiring you to first try diet programs or other medications)
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