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This raises a fundamental ethical question: For how long can it be ethically justifiedand not considered a form of misconductto withhold or fail to actively offer an evidence-based, disease-modifying therapy, when patients subsequently suffer preventable consequences such as reduced health span, premature mortality, sudden cardiac death, cancer or progressive complications of diabetes and other obesity-related diseases
Whether retatrutide's existing glucagon-receptor activation makes this additive or redundant is unstudied
For a pretty dead policy idea, bulk drug importation has had a lot of news lately
People who have diabetes or have used a diabetes drug in the previous 120 days have an additional requirement: they must try and fail treatment on one of the preferred diabetes treatment versions of the weight loss drugs, or another preferred diabetes drug in the same drug class (GLP-1 receptor agonists)
Weeks three through six are where the strategy starts working
What GLP-1s do in your body: Stimulate insulin release from pancreatic beta cells Slow gastric emptying, which reduces appetite Get metabolized primarily by the liver Are cleared partially through kidney function Have unknown long-term effects on thyroid C-cells Nearly half of patients stop GLP-1 therapy within the first year
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