PT-141 represents what happens when a promising lead compound is properly developed through clinic
In addition, it inhibits inflammation and carcinogenesis, reinforces the colonic defense barrier, modulates gut epithelium permeability, promotes satiety, increases sodium and water reabsorption (anti-diarrheal agent) and reduces oxidative stress 4
First, evaluate whether you have gradually increased portion sizes or reintroduced high-calorie foods as your body adapted to the medication
Note that some users report increased nausea when moving from triple to dual agonist, possibly due to the loss of GIP-mediated GI protection
More preferably, they are selective over PDE-3, more preferably still they are selective over PDE-3, PDE-4 and PDE-6
Discussing this option with your prescriber is worthwhile if dose escalation periods consistently produce palpitations or other significant symptoms