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Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione

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Tallen HH, Moore S, Stein WH: L-cystathionine in human brain

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IGF-1 LR3 bypasses that entire regulatory sequence and acts directly on tissue-level IGF-1 receptors, which is why research describes its signaling onset as faster and more direct than secretagogue-based approaches, though also more potent at the receptor level