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Hence, the facilitation of glutaminolysis leads to the accumulation of excess ammonia within cells, and a high concentration of ammonia is a potent inducer of autophagy 167 (Fig
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KEAP1 (Kelch-like ECH associated protein 1) is a cysteine-rich protein that functions as a chemical sensor of cellular redox tone, mediating activation of NRF2 (Itoh et al., 1999)
GLP-1 medications are not approved as a replacement for insulin in type 1 diabetes
We also wanted to look at all-cause mortality because GLP-1 receptor agonists have constantly expanding indications in cardiovascular disease, renal disease and other conditions like sleep apnea, Mavromatis added
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