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These findings highlight the important role of the carnitine pool as a bridge between cellular metabolism and epigenetic regulation and open the possibility of developing novel therapeutic strategies targeting specific metabolic and epigenetic targets

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Oxidative stress triggers lipid droplet accumulation in primary cultured hepatocytes by activating fatty acid synthesis

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-Butyrobetaine (-BB) -BB, formed by the oxidation of TMABA, is the immediate precursor to L-carnitine

As a result of the fact that at least some of the glutamate generated in the PAG reaction may be released directly into the cytosol (35, 36)