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Two downstream consequences are mechanistically central: nicotinamide is preserved for re-entry into the NAD+ salvage pathway (raising intracellular NAD+ availability), and SAM is preserved for other methylation reactions

Clinical Applications and Limitations Tiaminal B12 injections are used for treating vitamin B12 deficiency

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Gastrointestinal disorders such as Crohns disease[13], celiac disease[14] or those who have undergone gastric bypass surgery[15]