Turner KA, Rambhatla A, Schon S, et al
Consequences of Excess Vitamin B12 Vitamin B12 is water-soluble, and excess amounts in the body can be easily excreted through urine, making it less toxic
The headline findings: Weight loss matched GLP-1 comparators in both species at sufficiently high dose Tolerability was substantially better markedly less nausea, vomiting, and food aversion Mechanism centers on energy expenditure rather than appetite suppression, via glucagon receptor activation in the liver and adipose tissue and GIP-mediated effects on adipocyte function GLP-1 absence avoided the gut-brain nausea axis that drives the dropout rate of approved drugs The provocation: if you can get tirzepatide-level weight loss without the GLP-1 arm, why include it
10.3748/wjg.v22.i38.8638 World J
The effects were assessed through self-reports, performance tests, sleep latency tests, and polysomnography
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