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The extreme intensity and unpredictability of the pain associated with trigeminal neuralgia can lead to emotional distress, anxiety, depression, sleep disturbances, and social withdrawal

Gene expression analysis showed upregulation of survival pathways (Egr1, Akt1, Kras, Src, Foxo, Srf, VEGFR2, NOS1, NOS3) and downregulation of inflammatory mediators (NOS2, NFB)

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Its always best to speak with your doctor when adding new supplements to your regimen, particularly in an effort to avoid medication interactions." 2