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The observation that higher plasma concentrations of 2 can be achieved after oral delivery than for PZQ, coupled with the greater ex vivo potency of compound 2 , strongly suggest that further optimization will yield an orally bioavailable schistosomicidal agent that will be transformative in the clinical setting

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Among the resulting 11 firms, one European and one Chinese are likely part of submitted ANDA applications, based on the timing of their DMFs and the payment of GDUFA DMF user fees

Your doctor can help determine the best medication based on your health needs, past treatment responses, and other factors

Seek urgent care or emergency help for symptoms such as severe abdominal pain, persistent vomiting or diarrhea, signs of dehydration, trouble breathing or swallowing, swelling of the face, lips, tongue, or throat, fainting, yellowing skin or eyes, or any symptom your clinician has told you to treat as urgent