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Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons Implications for energy balance and glucose control
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McGill MR, Sharpe MR, Williams CD, Taha M, Curry SC, Jaeschke H
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That's what the big trials measured, and the answers were impressive, roughly 15% of body weight at semaglutide's full 2.4 mg dose and up to about 21% with tirzepatide