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The weight loss effects observed with these medications result from both delayed gastric emptying and direct effects on appetite centers in the hypothalamus, leading to reduced hunger and increased satiety
IAPAM overview)
Competing interests PG has received occasional fees, either personally or institutionally, for the activities of speaking, scientific advising, or clinical research from Abbott, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, Gilead, GlaxoSmithKline, Merck Sharp & Dohme, Novo Nordisk, Organon, Pfizer, and Sanofi
PMID: 34703584
The ratiometric FRET signal takes account of differences in the number of internalized receptors, and is indicative of avidity of binding
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