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Key takeaways Compounded medications are custom drugs made by licensed pharmacists and often sold to counteract drug shortages
HATs catalyze the addition of acetyl groups from the acyl donor acetyl-CoA, which can be produced by glucose, fatty acids, and BCAA metabolism (Figure 1), to lysine residues in histone tailsthus called histone acetylation
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The table below shows dosing for all three formulations: Egrifta SV (the current main product), Egrifta WR (a newer once-weekly-reconstitution version), and legacy Egrifta (the original 2 mg/day product used in trials)
Cheng HW, Yang SF, Liao PL, Lee CH, Jong GP
