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These in vivo findings dovetail with in vitro RF/6A data (227), and collectively suggest that adiponectin and clusterin, both influenced by metabolic fitness, contribute to retinal vascular resilience in diabetes

Hum Brain Mapp 41:194217 Mandal PK, Shukla D, Govind V, Boulard Y, Ersland L (2017) Glutathione conformations and its implications for in vivo magnetic resonance spectroscopy

[7] Vitamin B 12 activation Methyl-THF converts vitamin B 12 to methyl-B 12 (methylcobalamin)

That means the active is enclosed within a protective shell, usually made of lipids or polymers, to enhance its stability and improve delivery to the skin