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The STEP (Semaglutide Treatment Effect in People with obesity) 1 trial was a randomized, placebo-controlled trial that evaluated the efficacy of once-weekly subcutaneous (SC) semaglutide 2.4 mg plus lifestyle interventions in adults with obesity without diabetes (n = 1961)
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As their use has expanded, patients and healthcare providers have raised questions about potential cardiovascular risks, including whether these medications might increase the likelihood of blood clots (venous thromboembolism)
External resources Weight regain after liraglutide, semaglutide or tirzepatide (PubMed Central) Tirzepatide and metabolic adaptation in people with obesity (Cell Metabolism) Tirzepatide once weekly for the treatment of obesity (New England Journal of Medicine) Body weight reducing effects of tirzepatide review (PubMed Central) In case I do not see you, good afternoon, good evening, and good night