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X was perpendicular to the sagittal plane traversing from left to right sides of the nasal models (with the model head facing forward), Y was perpendicular to the axial plane traversing from inferior to superior aspects of the models, and Z was perpendicular to the coronal plane traversing from anterior to posterior aspects of the models

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J.et al (2019)

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Bibcode:2006AnRPB..57..805Z

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During lead optimization, less-sensitive cell assays are valuable for distinguishing the contributions of affinity and efficacy in the cellular response to an agonist ( 29 )

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