First, to quench all the free radicals we encounter from the sun, the oxygen we breathe, and it works to balance the by-products of our internal chemical reactions producing reactive oxygen and nitrogen species (ROS and NOS)
They are generally well-tolerated and considered safe when given as recommended
Hepatic Effects: Instruct patients to promptly stop taking alogliptin and pioglitazone tablets and seek immediate medical advice if they experience signs or symptoms of liver injury (e.g., unexplained nausea, vomiting, abdominal pain, fatigue, anorexia or dark urine) [see Warnings and Precautions (5.4)]
If you have received injections for several weeks and notice no change, tell your provider
doi: 10.4161/cbt.9.1.10392
Accessed October 23, 2025