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Following dosage instructions matters because overuse damages the liver (for acetaminophen) or kidneys and stomach (for NSAIDs)

doi: 10.1007/s13760-016-0697-z 165

These receptors influence appetite signaling, nutrient absorption, insulin sensitivity, and hepatic glucose production

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Finally, the biggest risk is for people who have pernicious anemia, a rare condition in which a person is unable to absorb any B12 through their stomach or intestines people with this condition are the ones who actually need B12 injections

Genetic variants do not determine treatment outcome but may inform personalization discussions