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In preclinical studies published in Endocrinology, researchers found that chronic administration of AOD-9604 reduced body weight and body fat in obese mice while increasing beta-3 adrenergic receptor expression to levels comparable with lean mice
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Why Do B12 Deficiencies Happen
What this data doesn't tell us: whether NNMT suppression sustained beyond 12 weeks alters NAD+ metabolism in ways that affect mitochondrial function, whether methylation pathway compensation occurs over longer timescales, or whether adipose tissue remodeling continues linearly or plateaus
Some patients may require imaging studies (ultrasound, CT scanning) or referral to hepatology, haematology, or oncology services
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