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Bioactivation of nephrotoxins and renal carcinogens by glutathione S-conjugate formation

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The timepoint chosen (when drug-tolerant cells are emerging after treatment) probably contributes to this effect, and later timepoints (when cells perhaps enter senescence or other more terminally arrested states) are more likely to reflect the expected gene expression patterns

If youre having side effects, your dose is too high. This delayed gastric emptying may lead to reduced efficacy of birth-control pills by reducing their absorption, though the research on this is still unclear

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Thus, interference with GSH synthesis in FoB induced an increase in mitochondrial mass without concomitant mtDNA replication