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Possibilities for therapies targeting cholesterol uptake in breast and ovarian cancers Cancers often upregulate the key cholesterol uptake molecules such as NPC1, NPC1-like 1 protein (NPC1L1), LDLR, SR-B1, and proprotein convertase subtilisin/kexin like 9 (PCSK9) making them the most logical targets of possible pharmaceutical interventions
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Some participants in trials also reported fatigue, though this was not uniformly documented across all study arms
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